Antitumor activity of cytoxan.

Among 1,000 selected compounds and antibiotics tested against all or portions of the tmnor spectrum (33 tumors), cytoxan was the most effective, having a marked inhibitory to complete inhibitory effect on ~6 out of 38 tumors. Cytoxan (50 mg /kg /day for mice; ~5 m g / k g / d a y for rats) had a destructive effect on well established 7-day-old Sarcoma T5~41, Carcinoma 10~5, Lewis bladder carcinoma, Wagner and Ridgway osteogenic sarcomas, Mecca lymphosarcoma, and Leukemia L 4946 in mice; and Flexner-Jobling carcinoma, Walker carcinosarcoma ~56, Jensen sarcoma, Iglesias sarcoma, Moore sarcoma No. 1, and Murphy-Sturm lymphosarcoma in rats. Repeated intraperitoneal injections of cytoxan had a moderate inhibitory effect on spontaneous mammary adenocarcinomas in mice and a slight inhibitory effect on well established sarcomas induced by methylcholanthrene in mice, but there was no complete tumor regression.